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| Registros recuperados : 10 | |
| 1. |  | VENTURA, J. P.; LACERDA JÚNIOR, G. V.; NISHISAKA, C. S.; BISSON-FILHO, A.; FERNANDES-JÚNIOR, P. I.; MELO, I. S. de. Harnessing haloarchaea from atriplex nummularia rhizosphere to enhance salt tolerance in maize seedlings: insights into plant-microbe interactions. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu. Resumos... São Paulo: Sociedade Brasileira de Microbiologia, 2023. Resumo: 1285-1. 1 p.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 2. | | SILVA, A. M. M.; FEILER, H. P.; QI, X.; ARAÚJO, V. L. V. P. de; LACERDA JÚNIOR, G. V.; FERNANDES JUNIOR, P. I.; CARDOSO, E. J. B. N. Impact of water shortage on soil and plant attributes in the presence of arbuscular mycorrhizal fungi from a harsh environment. Microorganisms, v. 11, n. 5, 1144, 2023.| Biblioteca(s): Embrapa Semiárido. |
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| 5. | | LACERDA JÚNIOR, G. V.; NORONHA, M. F.; SOUSA, S. T. P. de; CABRAL, L.; DOMINGOS, D. F.; SÁBER, M. L.; MELO, I. S. de; OLIVEIRA, V. M. Potential of semiarid soil from Caatinga biome as a novel source for mining lignocellulose-degrading enzymes. FEMS Microbiology Ecology, v. 93, n. 2, p. 1-15, 2017.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 6. | | SILVA, L. J. da; CREVELIN, E. J.; SOUZA, D. T.; LACERDA JÚNIOR, G. V.; OLIVEIRA, V. M.; RUIZ, A. L. T. G.; ROSA, L. H.; MORAES, L. A. B.; MELO, I. S. de. Actinobacteria from Antarctica as a source for anticancer discovery. Scientific Reports, v. 10, article 13870, 2020. p. 1-15.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 7. | | SILVA, A. M. M.; JONES, D. L.; CHADWICK, D. R.; QI, X.; COTTA, S. R.; ARAÚJO, V. L. V. P.; MATTEOLI, F. P.; LACERDA-JÚNIOR, G. V.; PEREIRA, A. P. A.; FERNANDES JUNIOR, P. I.; CARDOSO, E. J. B. N. Can arbuscular mycorrhizal fungi and rhizobacteria facilitate P33 uptake in maize plants under water stress? Microbiological Research, v. 271, 127350, 2023.| Biblioteca(s): Embrapa Semiárido. |
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| 8. | | LACERDA JÚNIOR, G. V.; PASTORE, R. A. A.; DELFORNO, T. P.; CENTURION, V. B.; NORONHA, M. F.; VENTURA, J. P.; SARTORATTO, A.; MELO, I. S. de; OLIVEIRA, V. M. Taxonomic and functional dynamics of the soil microbiome from a tropical dry forest in kraft lignin-amended microcosms. Applied Soil Ecology, V. 183, article 104766, 2023.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 9. | | OTTONI, J. R.; CABRAL, L.; SOUSA, S. T. P. de; LACERDA JUNIOR, G. V.; DOMINGOS, D. F.; SOARES JUNIOR, F. L.; SILVA, M. C. P. da; MARCON, J.; DIAS, A. C. F.; MELO, I. S. de; SOUZA, A. P. de; ANDREOTE, F. D.; OLIVEIRA, V. M. de. Functional metagenomics of oil-impacted mangrove sediments reveals high abundance of hydrolases of biotechnological interest. World Journal of Microbiology and Biotechnology, v. 33, n. 7, p. 1-13, 2017. Article 141.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 10. | | SILVA, A. M. M.; FEILER, H. P.; LACERDA-JÚNIOR, G. V.; FERNANDES JUNIOR, P. I.; AIDAR, S. de T.; ARAÚJO, V. A. V. P. de; MATTEOLI, F. P.; PEREIRA, A. P. de A.; MELO, I. S. de; CARDOSO, E. J. B. N. Arbuscular mycorrhizal fungi associated with the rhizosphere of an endemic terrestrial bromeliad and a grass in the Brazilian neotropical dry forest Brazilian Journal of Microbiology, v, 54, n. 3, p. 1955-1967, Sept. 2023.| Biblioteca(s): Embrapa Meio Ambiente; Embrapa Semiárido. |
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| Registros recuperados : 10 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
29/12/2020 |
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Data da última atualização: |
29/12/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SILVA, L. J. da; CREVELIN, E. J.; SOUZA, D. T.; LACERDA JÚNIOR, G. V.; OLIVEIRA, V. M.; RUIZ, A. L. T. G.; ROSA, L. H.; MORAES, L. A. B.; MELO, I. S. de. |
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Afiliação: |
LEONARDO JOSÉ SILVA, ESALQ-USP; EDUARDO JOSÉ CREVELIN, FFCLRP-USP; DANILO TOSTA SOUZA, FFCLRP-USP; GILENO VIEIRA LACERDA JÚNIOR; VALERIA MAIA DE OLIVEIRA, CPQBA-UNICAMP; ANA LUCIA TASCA GOIS RUIZ, FCF-UNICAMP; LUIZ HENRIQUE ROSA, UFMG; LUIZ ALBERTO BERALDO MORAES, FFCLRP-USP; ITAMAR SOARES DE MELO, CNPMA. |
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Título: |
Actinobacteria from Antarctica as a source for anticancer discovery. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Scientific Reports, v. 10, article 13870, 2020. |
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Páginas: |
p. 1-15. |
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ISSN: |
2045-2322 |
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DOI: |
https://doi.org/10.1038/s41598-020-69786-2 |
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Idioma: |
Inglês |
|
Conteúdo: |
Abstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7), glioblastoma (U251), lung/non-small (NCI-H460) and kidney (786-0) human cancer cell lines. Cinerubin B and actinomycin V were the predominant compounds identified in Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653, respectively. Our results suggest that the rhizosphere of D. antarctica represents a prominent reservoir of bioactive actinobacteria strains and reveals it as an important environment for potential antitumour agents. MenosAbstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7)... Mostrar Tudo |
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Palavras-Chave: |
Anticancer activity; Antitumoral activity. |
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Thesagro: |
Bactéria não Patogênica; Câncer. |
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Thesaurus NAL: |
Actinobacteria; Antarctica. |
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Categoria do assunto: |
S Ciências Biológicas |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/219757/1/Melo-Actinobacteria-Antarctica-2020.pdf
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Marc: |
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001 2128824
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008 2020 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $ahttps://doi.org/10.1038/s41598-020-69786-2$2DOI
100 1 $aSILVA, L. J. da
245 $aActinobacteria from Antarctica as a source for anticancer discovery.$h[electronic resource]
260 $c2020
300 $ap. 1-15.
520 $aAbstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7), glioblastoma (U251), lung/non-small (NCI-H460) and kidney (786-0) human cancer cell lines. Cinerubin B and actinomycin V were the predominant compounds identified in Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653, respectively. Our results suggest that the rhizosphere of D. antarctica represents a prominent reservoir of bioactive actinobacteria strains and reveals it as an important environment for potential antitumour agents.
650 $aActinobacteria
650 $aAntarctica
650 $aBactéria não Patogênica
650 $aCâncer
653 $aAnticancer activity
653 $aAntitumoral activity
700 1 $aCREVELIN, E. J.
700 1 $aSOUZA, D. T.
700 1 $aLACERDA JÚNIOR, G. V.
700 1 $aOLIVEIRA, V. M.
700 1 $aRUIZ, A. L. T. G.
700 1 $aROSA, L. H.
700 1 $aMORAES, L. A. B.
700 1 $aMELO, I. S. de
773 $tScientific Reports$gv. 10, article 13870, 2020.
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